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Immunotherapies have yielded impressive clinical benefits in a growing number of cancers, and in many cases, they have surpassed the efficacy of existing therapies. Immunotherapy usage is expected to increase in cancer care with the rapid approval of several new drugs and expanded indications for existing drugs in this class. However, the expanding armamentarium of immunotherapies available to treat patients with cancer poses a challenge to community clinicians with respect to integrating this new class of agents into practice. Community cancer programs need guidance regard the practical issues that cancer programs must navigate to provide immunotherapy safely and effectively in their own communities.