Learning Objectives:

• Describe the Hippo pathway and how it can mediate signals between extracellular cues and intracellular changes

• Identify the phenotype observed when Lats1/2 is lost in CC10+ve cells compared to other resident stem cells of the lung

• Describe how the changes in Lats1/2 KO mice mimics what has been observed before in certain ILDs

• Describe how KO-specific epithelium may promote crosstalk with immune populations in the lung as well as circulating immune cells.

• Describe role of γδ T cells in lung inflammation

• Discuss how epithelial/immune crosstalk are important to many different diseases and infections in the lung.

Adeline Matschulat, presenter, has no relevant financial relationships to disclose.