The learning objectives:

• An overview of Legionella pneumophila and Legionnaires disease
• Data from a mouse model suggests increased IL27 and IL27 receptor expression in Legionella infection
• Total-seq/CITE-seq data analysis shows increased expression of co-stimulatory receptors on T cells
• IL27 receptor deficient mice are protected from Legionella infection; further mechanistic and validation studies are ongoing

Archana Jayaraman, Ph.D., presenter, has no relevant financial relationships to disclose.